First trimester maternal infections and offspring congenital heart defects: a meta-analysis
First-trimester maternal infections are associated with increased risk of offspring CHD and appear to extend beyond infections commonly tested for during routine pregnancy screening. Larger-scale studies are warranted to confirm these findings using laboratory antibody testing and explore underlying mechanisms.
Authors
- Christina Chambers (ORCID: https://orcid.org/0000-0003-4675-7722)
- Kazem Rahimi (ORCID: https://orcid.org/0000-0002-4807-4610)
- Nathalie Conrad (ORCID: https://orcid.org/0000-0001-5027-5481)
- Els Troost (ORCID: https://orcid.org/0000-0001-7920-8661)
- Pieter De Meester (ORCID: https://orcid.org/0000-0002-3865-0506)
- Alexander Van De Bruaene (ORCID: https://orcid.org/0000-0002-0469-8640)
- Art Schuermans (ORCID: https://orcid.org/0000-0001-8146-9692)
- Mark Woodward (ORCID: https://orcid.org/0000-0001-9800-5296)
- Werner Budts (ORCID: https://orcid.org/0000-0001-5850-5413)
- Terence Dwyer (ORCID: https://orcid.org/0000-0002-2091-7663)
- Karl Morten (ORCID: https://orcid.org/0000-0001-6926-6550)
- Tim Waterboer (ORCID: https://orcid.org/0000-0002-0616-6963)
- Jianrong He (ORCID: https://orcid.org/0000-0003-3837-5126)
- Huimin Su (ORCID: https://orcid.org/0009-0004-0639-9507)
- Edie Guo
Institutions
- Broad Institute (US)
- Royal Children's Hospital (AU)
- University of San Diego (US)
- German Cancer Research Center (DE)
- The George Institute for Global Health (GB)
- Heidelberg University (DE)
- Universitair Ziekenhuis Leuven (BE)
- John Radcliffe Hospital (GB)
- UNSW Sydney (AU)
- University of California San Diego (US)
- University of Oxford (GB)
- Guangzhou Women and Children Medical Center (CN)
- The George Institute for Global Health (AU)
- Murdoch Children's Research Institute (AU)
- Imperial College London (GB)
- Guangzhou Medical University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1093/eurheartj/ehaf564
- Citations
- 5
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Wellcome Trust
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- China Scholarship Council