The Effectiveness of Moringa Leaf Extract Ointment (Moringa oleifera lam) In the Healing Process of Incision Wounds in Mice (Mus musculus)

Background: Wounds are a form of damage or loss of tissue in the body. The use of both modern and traditional medicines in wound healing itself aims to speed up the healing process. One of the traditional plants that can be used as medicine is moringa leaf (moringa oleifera lam). Objective: The aim of this study is to knowing the effectiveness of moringa leaf extract ointment (moringa oleifera lam) in the healing process of incision wounds in mice (mus musculus). Methods: This study uses a true experiment design research design with a post test control group. The sampling technique is using purposive quota sampling and sample grouping by randomization. Samples divided into 4 groups consisted of aquades group, moringa leaf extract ointment group 5%, 10%, and 15%. The wound healing was valuation by measuring the length of the wound using a caliper and macroscopic observation of fibroblast growth. The study analysed in univariate and bivariate by Kruskal-Wallis test and continued with post hoc LSD test. Result: Bivariate analysis result shows there is a significant difference of giving moringa leaf extract ointment (moringa oleifera lam) to the length of closing of the mice incision wound (Mus musculus) with significance value p < 0,05 on the 3rd day (p= 0,001) and 7th (p = 0,000). The results of the stung number of fibroblasts showed that Moringa leaf extract ointment with a concentration of 5% had the largest increase in the number of fibroblasts compared to other groups. Conclusion: There is a significant difference effect of giving moringa leaf extract ointment (moringa oleifera lam) on the healing process of incision wounds in mice (mus musculus) with a concentration of 5%.