Metabolic Dysfunction-associated Steatotic Liver Disease in Klinefelter Syndrome: High Prevalence Uncovers an Unmet Need
This first study highlights substantial MASLD prevalence in patients with KS (45.1%). Metabolic syndrome is the major independent predictor of MASLD with a negative correlation between CAP and IGF-1. Early identification of MASLD is crucial to address the elevated risk of metabolic complications in this vulnerable population.
Authors
- Marco La Montagna
- Lucia Digitale Selvaggio (ORCID: https://orcid.org/0009-0002-5680-2670)
- Alfredo Caturano (ORCID: https://orcid.org/0000-0001-7761-7533)
- Ferdinando Carlo Sasso (ORCID: https://orcid.org/0000-0002-9142-7848)
- R. Navarra
- Daniela Pasquali (ORCID: https://orcid.org/0000-0002-5674-635X)
- Aldo Marrone (ORCID: https://orcid.org/0000-0001-7329-4159)
- Francesca Allosso
- Cosimo Ludovico
- Graziella Grande
- Martina Errico
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1210/clinem/dgaf479
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Università degli Studi della Campania Luigi Vanvitelli