Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025
We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case. Whole genome sequencing revealed a strong genetic link between the Sabin-like poliovirus type 1 variant from the case and pre-VDPV1 and VDPV1 isolated from environmental samples collected in October 2024-April 2025, mostly in Jerusalem. Early detection was made possible by Israel's robust environmental surveillance and advanced sequencing technologies, enabling a rapid public health response.
Authors
- Leah Weiss
- Tatyana Kushnir
- Lester M. Shulman (ORCID: https://orcid.org/0000-0002-6385-894X)
- Danit Sofer
- Merav Weil (ORCID: https://orcid.org/0000-0002-4472-4081)
- Yaniv Lustig (ORCID: https://orcid.org/0000-0001-7949-5912)
- Neta S. Zuckerman (ORCID: https://orcid.org/0000-0001-6074-2100)
- Oran Erster (ORCID: https://orcid.org/0000-0003-4839-8997)
- Reut Gabai
- Keren Friedman
- Rinat Vasserman
- Itay Bar-Or
- Alex Aydenzon
- Ira Aguvaev
- Hagar Eliyahu
- Noa Bar-Liss
- Tal Butensky
- Daniel Avhar
Institutions
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Israel Ministry of Health (IL)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2025-08-28
- DOI
- https://doi.org/10.2807/1560-7917.es.2025.30.34.2500605
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Ministry of Health, State of Israel
- Centers for Disease Control and Prevention