Lats1/2 Differentially Modulate the Proliferative State of Dental Epithelial Progenitors and Ameloblasts in the Murine Incisor
YAP activation promotes the expansion of dental epithelial progenitors but not ameloblasts in vivo, suggesting irreversible differentiation during tooth renewal. However, when dissociated, some ameloblasts acquire plasticity. This offers a strategy to manipulate proliferation in dental epithelial cells under different conditions and may have broader applications in orthodontics, where a modular control of progenitors and differentiated cells is critical for ensuring safe stem cell-based treatments.
Authors
- Jimmy Kuang‐Hsien Hu (ORCID: https://orcid.org/0000-0003-1035-0779)
- Colleen Luong
- Wei Du (ORCID: https://orcid.org/0000-0002-7410-9194)
- Zhiyue Zhang (ORCID: https://orcid.org/0000-0003-0368-8843)
- Santosh Kumar Upadhyay (ORCID: https://orcid.org/0000-0001-5999-4351)
Institutions
- California NanoSystems Institute (US)
- University of California, Los Angeles (US)
- Sichuan University (CN)
Publication Details
- Journal
- Orthodontics and Craniofacial Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1111/ocr.70019
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan University
- West China Hospital, Sichuan University
- National Institute of Dental and Craniofacial Research
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles