Access to Pyrrolo- and Dihydropyrrolofuranthridones via Phosphine-Mediated MBH-Type/O-Acylation/Wittig Reaction Sequence
We disclose phosphine-mediated double annulation via a one-pot reaction for the construction of functionalized pyrrolofuranthridones. This one-pot protocol involves a Morita-Baylis-Hillman (MBH)-type/O-acylation/Wittig reaction sequence. Broad functional group tolerance is displayed, and a range of pyrrolofuranthridones are obtained in good to high yields. Furthermore, this methodology has been successfully extended to indoline <i>N</i>-alkynamides as substrates for the synthesis of dihydropyrrolofuranthridones in high yields.
Authors
- Yadav Kacharu Nagare (ORCID: https://orcid.org/0000-0002-2752-7457)
- Wenwei Lin (ORCID: https://orcid.org/0000-0002-1121-072X)
- Gangababu Marri (ORCID: https://orcid.org/0009-0007-2593-1580)
- Raghunath Maruti Walunj
Institutions
- National Taiwan Normal University (TW)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1021/acs.orglett.5c01323
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Taiwan Normal University
- National Science and Technology Council