Genetic polymorphism of circumsporozoite protein of Plasmodium falciparum isolates in children in Brazzaville, Republic of Congo
This study provides baseline data on Pfcsp genetic diversity in a defined area of the Republic of Congo. The results highlight the degree of variation in natural parasite populations at gene loci relevant to vaccine-targeted epitopes of (PfCSP) antigen. Further research incorporating immunological data will be needed to conduct in-depth assessments of vaccine efficacy.
Authors
- Jean Claude Djontu (ORCID: https://orcid.org/0000-0002-5035-4515)
- Abel Lissom (ORCID: https://orcid.org/0000-0001-8859-6264)
- Marcel Tapsou Baina (ORCID: https://orcid.org/0009-0008-4888-3363)
- Francine Ntoumi (ORCID: https://orcid.org/0000-0003-4748-050X)
- Alain Maxime Mouanga (ORCID: https://orcid.org/0000-0001-8825-1864)
- Viny Andzi Elenga
- Claujens Chastel Mfoutou Mapanguy (ORCID: https://orcid.org/0000-0002-1408-4765)
- Jacque Dollon Mbama Ntabi
- Armelie Gomie Kathia Eouasse
Institutions
- University of Bamenda (CM)
- Fondation Congolaise Pour La Recherche Médicale (CG)
- Ministry of Public Health (CM)
- Marien Ngouabi University (CG)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s12936-025-05502-7
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alexander von Humboldt-Stiftung
- European Commission
- Fondation Mérieux
- European and Developing Countries Clinical Trials Partnership