Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction
Treatment with digitoxin led to a lower combined risk of death from any cause or hospital admission for worsening heart failure than placebo among patients with heart failure and reduced ejection fraction who received guideline-directed medical therapy. (Funded by the German Federal Ministry of Research, Technology, and Space and others; DIGIT-HF EudraCT number, 2013-005326-38.).
Authors
- Johannes Schwab (ORCID: https://orcid.org/0000-0002-7144-3031)
- Sebastian Winkler (ORCID: https://orcid.org/0000-0002-0926-311X)
- Udo Bavendiek (ORCID: https://orcid.org/0000-0003-3911-2571)
- Sven Schallhorn
- Michael Böhm (ORCID: https://orcid.org/0000-0002-2976-2514)
- Armin Koch
- Eleonora Angelini
- Mircea‐Andrei Sandu (ORCID: https://orcid.org/0000-0002-9067-5831)
- Johann Bauersachs (ORCID: https://orcid.org/0000-0002-9341-117X)
- Welf Geller
- Samira Soltani (ORCID: https://orcid.org/0009-0008-3532-8205)
- Anika Großhennig (ORCID: https://orcid.org/0000-0003-1455-2474)
- Daniel Scheiber (ORCID: https://orcid.org/0000-0002-6352-2565)
- Martin Hülsmann (ORCID: https://orcid.org/0000-0001-7944-7363)
- Nele Henrike Thomas (ORCID: https://orcid.org/0000-0003-1133-0171)
- Christian Veltmann (ORCID: https://orcid.org/0000-0001-7587-1124)
- Rainer Hambrecht (ORCID: https://orcid.org/0000-0001-9834-9435)
- Andreas Rieth (ORCID: https://orcid.org/0000-0001-8944-1192)
- Christoph Schröder (ORCID: https://orcid.org/0000-0001-6177-1042)
- Georg Nickenig
- Marija Zdravković (ORCID: https://orcid.org/0000-0003-4059-0263)
- Philipp Lurz (ORCID: https://orcid.org/0000-0002-5993-4487)
- Sören Wiesner
- Dragana Kosevic
- Barbara Neuhaus
- Dominik Berliner (ORCID: https://orcid.org/0000-0002-5710-3540)
- Stefan Störk (ORCID: https://orcid.org/0000-0002-1771-7249)
- Xiaofei Liu (ORCID: https://orcid.org/0000-0001-8559-0000)
- Thomas Gaspar (ORCID: https://orcid.org/0000-0002-8110-6290)
- Sebastian Philipp (ORCID: https://orcid.org/0000-0002-2111-7027)
- Heiko von der Leyen
- Lars S. Maier
- Peter Moritz Becher (ORCID: https://orcid.org/0000-0003-4648-8251)
- Fabian Rathje
- Anika Seltmann
Institutions
- University of Bremen (DE)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Bonn (DE)
- Karolinska Institutet (SE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- Düsseldorf University Hospital (DE)
- Städtisches Klinikum Dresden (DE)
- Universitätsklinik für Neurologie (AT)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsklinikum des Saarlandes (DE)
- Stockholm South General Hospital (SE)
- Unfallkrankenhaus Berlin (DE)
- Paracelsus Medizinische Privatuniversität (DE)
- Institute for Cardiovascular Diseases of Vojvodina (RS)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- Kerckhoff Klinik (DE)
- Elbe Kliniken Stade-Buxtehude (DE)
- Klinikum Links der Weser (DE)
- Universitätszahnklinik Wien (AT)
- University Hospital Medical Center Bezanijska kosa (RS)
- Senseonics (United States) (US)
- Heinrich Heine University Düsseldorf (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1056/nejmoa2415471
- Citations
- 39
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 54.14
Funders
- Bundesministerium für Bildung und Forschung
- Medizinischen Hochschule Hannover
- Deutsche Herzstiftung