Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias
Among participants with any cardiovascular disease who had an ICD and were at high risk for ventricular arrhythmias, a treatment-induced increase in plasma potassium levels led to a significantly lower risk of appropriate ICD therapy, unplanned hospitalization for arrhythmia or heart failure, or death from any cause than standard care. (Funded by the Independent Research Fund Denmark and others; POTCAST ClinicalTrials.gov number, NCT03833089.).
Authors
- Christian Jøns (ORCID: https://orcid.org/0000-0002-1876-2623)
- Ulrik Winsløw (ORCID: https://orcid.org/0000-0002-2165-9555)
- Hillah Saffi (ORCID: https://orcid.org/0000-0002-7977-2067)
- Helle Skovmand Bosselmann (ORCID: https://orcid.org/0000-0001-5910-0354)
- E. Michael Danielsen (ORCID: https://orcid.org/0000-0001-5725-2282)
- Niels Eske Bruun (ORCID: https://orcid.org/0000-0002-5026-9193)
- Henning Bundgaard (ORCID: https://orcid.org/0000-0002-0563-7049)
- Ketil Haugan (ORCID: https://orcid.org/0000-0001-5584-8445)
- Tharsika Sakthivel (ORCID: https://orcid.org/0000-0001-5744-7311)
- Niels Risum (ORCID: https://orcid.org/0000-0002-0357-9164)
- Kasper Karmark Iversen (ORCID: https://orcid.org/0000-0003-0504-8487)
- Chaoqun Zheng (ORCID: https://orcid.org/0000-0002-3248-8560)
- Emil Frandsen
- Sadjedeh S. Vakilzadeh-Hashemi
Institutions
- University of Copenhagen (DK)
- Roskilde Sygehus (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1056/nejmoa2509542
- Citations
- 15
- Primary Topic
- Potassium and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 22.78
Funders
- Hjerteforeningen
- Novo Nordisk Fonden
- Danmarks Frie Forskningsfond