Radiation-sensitive circRNA promotes intestinal regeneration
CircDmbt1(3,4,5,6), a novel promising RIII bio-marker, responses rapidly at the early stage after 14 Gy abdominal irradiation, and exogenous expression of circDmbt1(3,4,5,6) could promote intestinal fitness in RIII. We reveal that the circDmbt1(3,4,5,6)/miR-125a-5p/STAT3 axis is important to the regeneration of the intestinal epithelium after radiation-induced damage, providing a potential diagnostic and therapeutic target for RIII.
Authors
- M. Zhang (ORCID: https://orcid.org/0000-0002-2248-0290)
- Kaihua Ji
- Shiyun Ai (ORCID: https://orcid.org/0000-0003-0449-3677)
- Qingshan Yang (ORCID: https://orcid.org/0000-0001-9277-0026)
- Qianying Lu (ORCID: https://orcid.org/0000-0002-0810-4483)
- Xinyu Zhang
- Yan Wang (ORCID: https://orcid.org/0000-0003-1653-4122)
- Qiang Liu (ORCID: https://orcid.org/0000-0001-5811-1289)
- Ying Li (ORCID: https://orcid.org/0000-0002-3308-906X)
- Di Zhao
- Hao Sun
- Hongyu Cai (ORCID: https://orcid.org/0009-0009-1010-0957)
- Xin M. Liang (ORCID: https://orcid.org/0000-0001-8958-5129)
Institutions
- Tianjin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Soochow University (CN)
- Tianjin Medical University (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s11658-025-00782-y
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Soochow University