Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling
This study revealed activation of YAP1-mediated signaling in APS dermal microvessels and demonstrated that the YAP1 target CCN2 plays a role in facilitating pro-proliferative communication between MVECs and vascular smooth muscle cells. These findings offer insights into the cellular and molecular mechanisms underlying APS vasculopathy, providing potential therapeutic targets for patients.
Authors
- Jacqueline A. Madison (ORCID: https://orcid.org/0000-0003-1745-8133)
- Pei‐Suen Tsou (ORCID: https://orcid.org/0000-0002-7149-9115)
- Gabriel Figueroa‐Parra (ORCID: https://orcid.org/0000-0002-6077-8899)
- Alí Duarte‐García (ORCID: https://orcid.org/0000-0003-1749-5719)
- Zhixia Yang
- Hui Shi (ORCID: https://orcid.org/0000-0002-3574-8807)
- Wenying Liang (ORCID: https://orcid.org/0000-0001-9985-6674)
- Srilakshmi Yalavarthi (ORCID: https://orcid.org/0009-0005-9128-572X)
- Yu Zuo (ORCID: https://orcid.org/0000-0001-6721-7755)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- Yiran Shen (ORCID: https://orcid.org/0000-0002-4220-6862)
- Cyrus Sarosh (ORCID: https://orcid.org/0009-0004-5371-1700)
- Chengde Yang (ORCID: https://orcid.org/0000-0002-3720-634X)
- Ajay Tambralli (ORCID: https://orcid.org/0000-0001-9056-9513)
- Jason S. Knight (ORCID: https://orcid.org/0000-0003-0995-9771)
- Allison C. Billi (ORCID: https://orcid.org/0000-0001-7115-9113)
- Haoyu Pan (ORCID: https://orcid.org/0009-0009-7713-0659)
- Pooja Middha (ORCID: https://orcid.org/0000-0001-5503-8215)
- Rachael Bogle (ORCID: https://orcid.org/0000-0003-3544-3023)
- Shi Yue (ORCID: https://orcid.org/0000-0001-5861-1427)
- Zetao Ding (ORCID: https://orcid.org/0009-0006-6949-1700)
- Lucas Hudgins (ORCID: https://orcid.org/0009-0002-7850-7250)
- Caroline E. Vance
- Claire K. Hoy
- Qiuyu Wang (ORCID: https://orcid.org/0009-0006-9422-7223)
Institutions
- Mayo Clinic (US)
- Shanghai University of Sport (CN)
- Fudan University (CN)
- University of Michigan (US)
- Ruijin Hospital (CN)
- Michigan Medicine (US)
- Mayo Clinic in Arizona (US)
- Zhongshan Hospital (CN)
- Norwegian Womens Public Health Association (NO)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1161/circulationaha.125.073552
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30