Reduction of Antihypertensive Treatment in Nursing Home Residents
Among older nursing home residents with frailty who were receiving treatment with antihypertensive agents and had a systolic blood pressure below 130 mm Hg, an antihypertensive treatment step-down strategy did not lead to lower all-cause mortality than usual care. (Funded by the French Ministry of Health and others; RETREAT-FRAIL ClinicalTrials.gov number, NCT03453268.).
Authors
- Jean‐Baptiste Beuscart (ORCID: https://orcid.org/0000-0002-0734-8371)
- Olivier Hanon (ORCID: https://orcid.org/0000-0002-4697-122X)
- Jean‐Luc Novella (ORCID: https://orcid.org/0000-0002-7074-7500)
- Patrick Rossignol (ORCID: https://orcid.org/0000-0001-8009-3873)
- Patrick Karcher (ORCID: https://orcid.org/0000-0001-6149-8437)
- Patrick Manckoundia (ORCID: https://orcid.org/0000-0002-5518-9803)
- Anne Freminet
- François Bertin‐Hugault
- Carlos Labat (ORCID: https://orcid.org/0000-0002-5275-3405)
- Eric Vicaut
- Athanase Bénétos (ORCID: https://orcid.org/0000-0002-5197-1515)
- Abdourahmane Diallo
- Ioannis Georgiopoulos
- A. Metz
- Sylvie Gautier
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Princess Grace Hospital Centre (MC)
- Centre Hospitalier Universitaire de Lille (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Hôpital Broca (FR)
- Hôpital Lariboisière (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Hôpital Maison Blanche (FR)
- French Clinical Research Infrastructure Network (FR)
- Université de Strasbourg (FR)
- Université de Lorraine (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1056/nejmoa2508157
- Citations
- 17
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 23.60
Funders
- Agence Nationale de la Recherche
- Ministère de la Santé