Synergic effect of combined melatonin and tofacitinib on ameliorating dextran sulfate sodium-induced colitis in rat---role of JAKs/STAT, cell-stress signaling, and inflammatory-immune reaction
Combined melatonin-tofacitinib treatment effectively protected the colon against dextran sulfate sodium-induced damage, mainly through the suppression of Janus kinase family-signal transducer and activator of transcriptions/cell-stress signaling, inflammation, and oxidative stress.
Authors
- Chia‐Lo Chang
Institutions
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- American journal of clinical and experimental immunology.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.62347/fxyy2658
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung University
- Chang Gung Medical Foundation
- Kaohsiung Chang Gung Memorial Hospital