Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation
NFM, age-dependent maturation function, and GST enzyme activity may contribute to busulfan PK variability. The WT-based dosing strategy showed a higher risk of SOS than the age-based dosing strategy in 9-16 kg patients.
Authors
- Zhonglin Wei (ORCID: https://orcid.org/0000-0002-9032-0889)
- Xin Jiang (ORCID: https://orcid.org/0000-0002-1535-5846)
- Xiaowen Qian (ORCID: https://orcid.org/0000-0002-0072-6632)
- Ying Yu (ORCID: https://orcid.org/0000-0002-5693-0755)
- Ling Yu (ORCID: https://orcid.org/0000-0002-2115-3925)
- Xiaowen Zhai (ORCID: https://orcid.org/0000-0002-3505-0302)
- Junjun Mao (ORCID: https://orcid.org/0000-0003-4219-5953)
- Ping Wang (ORCID: https://orcid.org/0000-0001-7277-0520)
- Xinyi Zheng (ORCID: https://orcid.org/0000-0002-1869-4077)
- Di Cao (ORCID: https://orcid.org/0000-0002-2854-1285)
- Wenjin Jiang
- Shan Huang (ORCID: https://orcid.org/0009-0003-3241-1752)
Institutions
- Fudan University (CN)
- Soochow University (CN)
- Children's Hospital of Fudan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fphar.2025.1632588
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University