Acute and sub-acute toxicity assessment of methanolic stem bark extract of Khaya anthotheca (Meliaceae) in Wistar rats
The methanolic stem bark extract of K. anthotheca is practically non-toxic at acute dose of 5000 mg/kg b.wt, and safe for clinical use at low sub-acute doses of 125 mg/kg b.wt. However, long-term administration of high extract doses above 125 mg/kg was toxic to mainly the liver and stomach. Thus, long-term administration of high dosage of methanol stem bark extract of K. anthotheca, and phytomedicine development should be done with cautions of potential side effects.
Authors
- Savina Asiimwe
- Betty Akwongo (ORCID: https://orcid.org/0000-0002-7855-2935)
- Esezah Kakudidi (ORCID: https://orcid.org/0000-0003-3808-4126)
- Mary Namaganda (ORCID: https://orcid.org/0000-0002-1665-8929)
- Godwin Anywar (ORCID: https://orcid.org/0000-0003-0926-1832)
- Esther Katuura (ORCID: https://orcid.org/0000-0002-1780-4596)
- Patience Tugume (ORCID: https://orcid.org/0000-0002-2965-6500)
- Anthony M. Nsubuga
- Morgan Andama
Institutions
- Muni University (UG)
- Makerere University (UG)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Tropical Medicine and Health
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s41182-025-00721-9
- Citations
- 2
- Primary Topic
- Moringa oleifera research and applications
- Type
- article
- Field-Weighted Citation Impact
- 3.50