Hha toxin regulates diverse phenotypes of uropathogenic Proteus mirabilis including virulence
We disclosed that P. mirabilis Hha of the toxin-antitoxin system (TA) participates in virulence and its regulation by copper-sensing CpxR. This work provides Hha as a potential drug target for combating P. mirabilis urinary tract infections and opens new perspectives for studying TA aiming at controlling bacterial virulence.
Authors
- Cheng‐Yen Kao (ORCID: https://orcid.org/0000-0001-8782-3912)
- Yueh-Jung Chao
- Shwu‐Jen Liaw
- Yuan‐Ju Lee
- Hsuan- Hsuan Chen
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jmii.2025.08.016
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology
- Ministry of Science and Technology, Taiwan
- National Taiwan University Hospital