A novel home-based, combined occipital and trigeminal afferent stimulation therapy for major depressive disorder: Efficacy and safety results from a double-blind multicenter randomized sham-controlled study
This home-based brain neuromodulation system is safe and effective in treating depression. These findings support eCOT-AS as a promising new adjunct therapy for MDD patients with nonresponse to antidepressants.
Authors
- Mark S. George (ORCID: https://orcid.org/0000-0003-1767-1815)
- Andrew F. Leuchter (ORCID: https://orcid.org/0000-0003-2402-7083)
- Lisa Deutsch (ORCID: https://orcid.org/0000-0002-2445-7561)
- Linda L. Carpenter (ORCID: https://orcid.org/0000-0002-9651-3307)
- Nancy Navarro
Institutions
- Butler Hospital (US)
- Baptist Health South Florida (US)
- Neurobehavioral Systems (US)
- Ralph H. Johnson VA Medical Center (US)
- Statistical Service (CY)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.brs.2025.08.022
- Citations
- 2
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Abbott Laboratories
- Medical University of South Carolina
- BrainsWay
- National Institutes of Health