Isolated IgG elevation in patients with persistently normal transaminases does not affect the outcome of autoimmune hepatitis
The body of evidence showing a lesser impact of immunoglobulin G (IgG)values on outcomes in patients with autoimmune hepatitis (AIH) is growing. However, there is still a lack of robust information on the long-term outcomes, especially in patients who achieve persistent transaminase normalization. Persistently elevated IgG or IgG flares in patients with persistently normal transaminases do not seem to affect outcomes in patients with AIH. These results challenge the current definition of complete biochemical response in patients with AIH. Transaminase level normalization appeared to be the best treatment endpoint.
Authors
- Beatriz Muñoz (ORCID: https://orcid.org/0000-0003-0326-4119)
- María Del Barrio (ORCID: https://orcid.org/0000-0002-6276-7405)
- Bastian Engel (ORCID: https://orcid.org/0000-0002-0972-3454)
- Javier Crespo
- Johannes Hartl (ORCID: https://orcid.org/0000-0002-4037-9938)
- Manuel Rodríguez‐Perálvarez (ORCID: https://orcid.org/0000-0002-1795-2919)
- Ana Barreira‐Díaz (ORCID: https://orcid.org/0000-0002-4368-8939)
- Álvaro Díaz‐González (ORCID: https://orcid.org/0000-0003-3610-2263)
- Richard Taubert (ORCID: https://orcid.org/0000-0001-9270-2496)
- Christoph Schramm (ORCID: https://orcid.org/0000-0002-4264-1928)
- Alberto Gómez (ORCID: https://orcid.org/0000-0002-5592-3844)
- Ignasi Olivas (ORCID: https://orcid.org/0009-0008-0766-6864)
- Sergio Rodríguez‐Tajes (ORCID: https://orcid.org/0000-0002-3189-7557)
- Lorena Carballo‐Folgoso (ORCID: https://orcid.org/0000-0002-3473-5027)
- Mireia Miquel (ORCID: https://orcid.org/0000-0003-4566-4962)
- Ida Schregel (ORCID: https://orcid.org/0009-0001-2014-6838)
- Inmaculada Castelló (ORCID: https://orcid.org/0000-0002-2678-9711)
- Mar Riveiro‐Barciela (ORCID: https://orcid.org/0000-0001-9309-2052)
- Ana Arencibía (ORCID: https://orcid.org/0000-0002-7813-7563)
- Clara Isabel González (ORCID: https://orcid.org/0000-0002-0278-1512)
- Felix Volmer
- María‐Carlota Londoño (ORCID: https://orcid.org/0000-0002-6533-1586)
- Montserrat Garcı́a-Retortillo (ORCID: https://orcid.org/0000-0001-6783-7604)
- Diana Paola Bocanegra Horta (ORCID: https://orcid.org/0000-0002-3675-1135)
- Jesús M. González‐Santiago (ORCID: https://orcid.org/0000-0003-4667-4492)
- Magdalena Salcedo (ORCID: https://orcid.org/0000-0002-1239-5746)
- Manuel Hernández‐Guerra (ORCID: https://orcid.org/0000-0002-3478-9981)
- Judith Gómez (ORCID: https://orcid.org/0000-0003-4923-7466)
- Indhira Pérez‐Medrano (ORCID: https://orcid.org/0000-0001-6104-8612)
- Margarita Sala (ORCID: https://orcid.org/0000-0003-4879-1780)
- Carmen Álvarez‐Navascués (ORCID: https://orcid.org/0000-0002-9496-2133)
- Enrique Frisancho-Morales
Institutions
- Universität Hamburg (DE)
- Hospital Universitario de Canarias (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Medizinische Hochschule Hannover (DE)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Complejo Hospitalario de Salamanca (ES)
- Marqués de Valdecilla University Hospital (ES)
- University Medical Center Hamburg-Eppendorf (DE)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Universitario de Burgos (ES)
- Hospital Universitario Reina Sofía (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital General Universitario De Valencia (ES)
- Mútua Terrassa (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Parc de Salut (ES)
- Hospital Universitario Central de Asturias (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Institute of Research and Innovation Parc Tauli (ES)
- ERN GUARD-Heart (NL)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Complejo Hospitalario de Pontevedra (ES)
- Hospital Universitario Ramón y Cajal (ES)
- ERN RARE-LIVER (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101562
- Citations
- 3
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Asociación Española para el Estudio del Hígado
- European Commission
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover
- Instituto de Salud Carlos III