Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies
Model-based simulations suggest that a rational response to MMF dose omissions can mitigate underexposure while avoiding toxicity. These strategies may support clinicians in managing missed doses and optimizing immunosuppressive therapy in kidney transplant recipients.
Authors
- Pierre Marquet (ORCID: https://orcid.org/0000-0001-7698-0760)
- Yeleen Fromage (ORCID: https://orcid.org/0009-0002-3356-557X)
- Jean‐Baptiste Woillard (ORCID: https://orcid.org/0000-0003-1695-0695)
- Caroline Monchaud (ORCID: https://orcid.org/0000-0002-9637-5813)
- Hamza Sayadi
- Franck Maizaud (ORCID: https://orcid.org/0009-0002-5103-0827)
- Selim Arraki-Zava
Institutions
- Inserm (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Université de Limoges (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1371/journal.pone.0330854
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99
Funders
- Bristol-Myers Squibb
- Pfizer
- Gilead Sciences
- Astellas Pharma