HIV-1 controllers possess a unique CD8+ T cell activation phenotype and loss of control is associated with increased expression of exhaustion markers
These results suggest that CD8+ T cell exhaustion compromises the ability to control viral replication in HIV-1 controllers. The character of exhaustion in response to HIV-1 and therapy is distinct in HIV-1 persistent controllers, transient controllers and standard progressors.
Authors
- Zachary Klase (ORCID: https://orcid.org/0000-0002-2208-5768)
- Rachel Van Duyne (ORCID: https://orcid.org/0000-0003-2914-6874)
- Amber D. Jones
- Stephen M. Smith (ORCID: https://orcid.org/0000-0002-9158-6136)
- Zachary Capriotti
- Angel Lin
- Erin Santos
Institutions
- University of the Sciences (US)
- Thomas Jefferson University (US)
- Smith Family (AU)
- Sidney Kimmel Cancer Center (US)
- Drexel University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1371/journal.pone.0328706
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Drexel University
- National Institutes of Health
- National Institute on Drug Abuse