Gallbladder amyloidosis is often unexpected and may have systemic implications
In patients with clinical data, amyloidosis was often unexpected, the gallbladder was commonly the first tissue sampled with amyloidosis, and all patients had systemic disease. Thorough review of cholecystectomy specimens with careful inspection of perimuscular vessels, coupled with a low threshold for ordering Congo red stain in elderly individuals and amyloid typing using a robust method such as proteomics, can prevent a delay in amyloid diagnosis and management.
Authors
- Angela A. Dispenzieri (ORCID: https://orcid.org/0000-0001-8780-9512)
- Morie A. Gertz (ORCID: https://orcid.org/0000-0002-3853-5196)
- Catherine E. Hagen (ORCID: https://orcid.org/0000-0002-1867-4957)
- Daniel P. Larson (ORCID: https://orcid.org/0000-0002-2938-922X)
- Ellen D. McPhail (ORCID: https://orcid.org/0000-0001-6918-3376)
- Linda N. Dao (ORCID: https://orcid.org/0000-0003-0048-5901)
- April Chiu (ORCID: https://orcid.org/0000-0002-6431-2666)
- Surendra Dasari (ORCID: https://orcid.org/0000-0002-7972-3556)
- Taxiarchis Kourelis (ORCID: https://orcid.org/0000-0001-8573-9434)
- Eli Muchtar (ORCID: https://orcid.org/0000-0003-2210-2174)
- Joanna Dalland (ORCID: https://orcid.org/0000-0002-6856-7746)
- Jason D. Theis (ORCID: https://orcid.org/0000-0001-7267-8409)
- Karen L. Rech (ORCID: https://orcid.org/0000-0001-6770-2339)
- Julie A. Vrana (ORCID: https://orcid.org/0000-0003-1083-8483)
- Matthew T. Howard
- Samih H. Nasr (ORCID: https://orcid.org/0000-0002-5542-6776)
Institutions
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ajcp/aqaf090
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00