CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1
CCHCR1 acts as a linker that recruits P-body proteins to the centrosome and is essential for cilia development. The recruitment of P-body proteins to the centrosome via CCHCR1 is also one of the mechanisms by which PCM1 and OFD1 are involved in ciliogenesis.
Authors
- Stephen Cho Wing Sze (ORCID: https://orcid.org/0000-0002-4561-1214)
- Qiwen Wu (ORCID: https://orcid.org/0000-0001-6112-9439)
- C. Li
- Shanqiang Zhang
- Junshan Zhang (ORCID: https://orcid.org/0000-0002-1226-1334)
Institutions
- Hong Kong Baptist University (HK)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Southwest Baptist University (US)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s11658-025-00780-0
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shantou University Medical College
- Salford Royal NHS Foundation Trust
- Basic and Applied Basic Research Foundation of Guangdong Province