Decreased low-frequency amplitude of the right caudate nucleus in patients with chronic schizophrenia treated with risperidone combined with clozapine
This exploratory analysis observed a more pronounced decrease in right caudate nucleus ALFF in the combination therapy group compared to the risperidone monotherapy group. The observed differences in neural activity patterns provide preliminary neuroimaging clues suggesting potential distinct neural effects between long-term monotherapy and combination therapy in chronic schizophrenia, and may offer new directions for exploring neuroimaging explanations for the combination therapy.
Authors
- Kwong‐Kum Liao (ORCID: https://orcid.org/0000-0003-4920-0639)
- Sen Peng (ORCID: https://orcid.org/0000-0002-3337-3749)
- Lixing Lei
- Ying Li (ORCID: https://orcid.org/0000-0001-5887-3937)
- Nian Liu (ORCID: https://orcid.org/0000-0002-3324-8606)
- Xinyue Chen (ORCID: https://orcid.org/0000-0003-3212-2398)
- Hangyu Li (ORCID: https://orcid.org/0000-0002-2570-1642)
- Rui Yu (ORCID: https://orcid.org/0000-0002-3634-8004)
Institutions
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fpsyt.2025.1630499
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China