Fear-learning is altered in a mouse neuropathic pain model
These findings indicate that a neuropathic pain model enhances learned context/cue evoked fear behaviours at an early stage following nerve-injury. Furthermore, fear-conditioning enhances anxiety-like behaviour, before such behaviour is normally developed. Thus, fear-conditioning induces exaggerated fear-learning which triggers enhanced fear and anxiety, even during early stages of chronic neuropathic pain.
Authors
- Neda Assareh (ORCID: https://orcid.org/0000-0001-8014-0967)
- Bryony L. Winters (ORCID: https://orcid.org/0000-0002-4973-0771)
- C.D. Frith
- Vanessa Mitchell
- Eddy Sokolaj (ORCID: https://orcid.org/0009-0009-8081-8227)
- Christopher W. Vaughan (ORCID: https://orcid.org/0000-0003-4314-7689)
- Kristen Anderson (ORCID: https://orcid.org/0009-0002-4488-5202)
- Saima Sadia
- Olivia B. Walls
Institutions
- The University of Sydney (AU)
- Royal North Shore Hospital (AU)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fpain.2025.1648374
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00