Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB
Large, clinically actionable allele-frequency contrasts and pronounced discovery biases confirm the need for ancestry-aware PGx testing and locally calibrated dosing algorithms in Colombia. The analytic framework and variant catalogue generated knowledge to operationalize precision pharmacotherapy across admixed Latin-American populations.
Authors
- Indiana Luz Rojas Torres (ORCID: https://orcid.org/0000-0003-1027-346X)
- Kevin Fernando Montoya-Quintero (ORCID: https://orcid.org/0000-0002-6212-7141)
- Johana Galván-Barrios (ORCID: https://orcid.org/0000-0003-2445-3680)
- Andy A. Acosta-Monterrosa (ORCID: https://orcid.org/0000-0002-6860-1043)
Institutions
- University of Cartagena (CO)
- University of the Coast (CO)
- Universidad de Manizales (CO)
- Universidad Simón Bolívar (CO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fphar.2025.1636451
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.56