Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice
Gossypol powder from cotton is toxic to mice, affecting their pathology, histology, and hematology. This study strongly links the <i>Dmrt2</i> gene in reproductive tissues to gossypol resistance, highlighting its potential protective role and advancing the understanding of gene regulation in mouse fertility. Further research and food safety considerations are therefore crucial.
Authors
- Teame Gereziher Mehari (ORCID: https://orcid.org/0000-0001-7749-1811)
- Hui Fang (ORCID: https://orcid.org/0000-0002-3992-0440)
- Maorong Jiang
- Jiaxi Qian
- Dandan Gu
- Jun Tang (ORCID: https://orcid.org/0000-0002-8290-2459)
- Ashenafi Kiros Wubshet (ORCID: https://orcid.org/0000-0002-9008-2075)
- Dengbing Yao (ORCID: https://orcid.org/0000-0002-5177-0318)
- Kai Wang (ORCID: https://orcid.org/0000-0002-1074-0438)
- Baohua Wang (ORCID: https://orcid.org/0000-0001-7449-8292)
Institutions
- Nantong University (CN)
- Jiangsu Agri-animal Husbandry Vocational College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fphar.2025.1654299
- Citations
- 1
- Primary Topic
- Research in Cotton Cultivation
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Government of Jiangsu Province
- Jiangsu Provincial Key Research and Development Program