SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation
These results underscore the key involvement of SIRT1-MOF axis in modulating H4K16 acetylation. Our findings provide mechanistic insights into H4K16 acetylation pathway in eSPTs and support the key role of H4K16ac in chromatin remodeling underlying histone displacement.
Authors
- Giulia Ricci (ORCID: https://orcid.org/0000-0002-2199-170X)
- Antonio Suglia (ORCID: https://orcid.org/0000-0003-3507-6403)
- Veronica Porreca
- Gilda Cobellis (ORCID: https://orcid.org/0000-0001-5884-9208)
- Antonella Migliaccio
- Vincenza Grazia Mele
- Concetta Ambrosino (ORCID: https://orcid.org/0000-0003-3954-8842)
- Mariano Stornaiuolo (ORCID: https://orcid.org/0000-0003-2200-5083)
- Rosanna Chianese (ORCID: https://orcid.org/0000-0003-3631-1794)
- Francesco Manfrevola (ORCID: https://orcid.org/0000-0003-0459-7644)
- Teresa Chioccarelli (ORCID: https://orcid.org/0000-0002-1720-1496)
- Francesco Albano (ORCID: https://orcid.org/0000-0001-7926-6052)
- Valeria Nittoli (ORCID: https://orcid.org/0000-0002-7411-4962)
Institutions
- Inserm (FR)
- University of Campania "Luigi Vanvitelli" (IT)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Biogem (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fcell.2025.1524919
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22