Advancing bioinformatics capacity through Nextflow and nf-core: lessons from an early-to mid-career researchers–focused program at The Kids Research Institute Australia

The increasing adoption of high-throughput "omics" technologies has heightened the demand for standardized, scalable, and reproducible bioinformatics workflows. Nextflow and nf-core provide a robust framework for researchers, particularly early- and mid-career researchers (EMCRs), to navigate complex data analysis. At The Kids Research Institute Australia, we implemented a structured approach to bioinformatics capacity building using these tools. This perspective presents nine practical rules derived from lessons learnt, which facilitated the successful adoption of Nextflow and nf-core, addressing implementation challenges, knowledge gaps, resource allocation, and community support. Our experience serves as a guide for institutions aiming to establish sustainable bioinformatics capabilities and empower EMCRs.

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Publication Details

Journal
Frontiers in Bioinformatics
Published
2025-08-29
DOI
https://doi.org/10.3389/fbinf.2025.1610015
Primary Topic
Genetics, Bioinformatics, and Biomedical Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Advancing bioinformatics capacity through Nextflow and nf-core: lessons from an early-to mid-career researchers–focused program at The Kids Research Institute Australia

Abhinav Sharma, Talya Conradie, Anthony Kicic, Stephen M. Stick et al.
Frontiers in Bioinformatics
Genetics, Bioinformatics, and Biomedical Research
article

Advancing bioinformatics capacity through Nextflow and nf-core: lessons from an early-to mid-career researchers–focused program at The Kids Research Institute Australia

Abhinav Sharma, Talya Conradie, Anthony Kicic, Stephen M. Stick, Christopher Hakkaart, Patricia Agudelo‐Romero, José A. Caparrós‐Martín, David Martino
article en

Abstract

The increasing adoption of high-throughput "omics" technologies has heightened the demand for standardized, scalable, and reproducible bioinformatics workflows. Nextflow and nf-core provide a robust framework for researchers, particularly early- and mid-career researchers (EMCRs), to navigate complex data analysis. At The Kids Research Institute Australia, we implemented a structured approach to bioinformatics capacity building using these tools. This perspective presents nine practical rules derived from lessons learnt, which facilitated the successful adoption of Nextflow and nf-core, addressing implementation challenges, knowledge gaps, resource allocation, and community support. Our experience serves as a guide for institutions aiming to establish sustainable bioinformatics capabilities and empower EMCRs.

Frontiers in BioinformaticsVol. 5
Australian Research Council (AU), The Kids Research Institute Australia (AU), The University of Western Australia (AU), Curtin University (AU), Princess Margaret Hospital for Children (AU), South African Tuberculosis Vaccine Initiative (ZA), Perth Children's Hospital, Friedrich Schiller University Jena (DE)
Government of Western Australia
Openalex Percentile: Top 80%
Genetics, Bioinformatics, and Biomedical Research
DOIOpen Access PDFOpenAlex
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