Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages
The N-Rgo/ZrO2+DPSCs composite promotes bone regeneration through dual mechanisms: (1) immunomodulation through M2 macrophage polarization and MAPK pathway activation and (2) direct osteogenic differentiation. This strategy demonstrates superior efficacy to individual components, offering a novel combinatorial approach for maxillofacial bone repair.
Authors
- Bingyao Liu (ORCID: https://orcid.org/0000-0002-7369-7019)
- Jiale Hu (ORCID: https://orcid.org/0000-0003-1993-8704)
- Yingying Wu (ORCID: https://orcid.org/0000-0002-5289-833X)
- Maodian He
- Cuimei Li (ORCID: https://orcid.org/0000-0002-5347-2584)
- Weihua Shang
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fbioe.2025.1632000
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00