Smarce1 fine-tunes cardiomyocyte proliferation in the embryonic zebrafish heart
These findings identify <i>smarce1</i> as a cell-autonomous, negative regulator of CM proliferation during zebrafish heart development. Our results highlight the role of SWI/SNF-mediated chromatin remodeling in developmental cardiac growth and suggest that Smarce1 may serve as an epigenetic modulator of cardiogenesis with relevance for future regenerative therapies.
Authors
- Deung-Dae Park (ORCID: https://orcid.org/0000-0001-6265-4964)
- Tillman Dahme (ORCID: https://orcid.org/0000-0002-6211-7162)
- Wolfgang Rottbauer (ORCID: https://orcid.org/0000-0003-4725-6217)
- Steffen Just (ORCID: https://orcid.org/0000-0001-7396-1281)
- L Krieg
Institutions
- Universität Ulm (DE)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fcell.2025.1636944
- Citations
- 2
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.61