The expression regulation of recA gene and bacterial class 2 integron-associated genes induced by antibiotics
Sub-MIC concentrations of drugs have been shown to induce an increase in the relative expression level of the SOS response-related gene <i>recA</i>, as well as the integrase and resistance genes of class 2 integrons. Continuous induction leads to sustained upregulation of these genes, which stabilizes or slightly decreases upon reaching a plateau. However, the capacity of different drugs to induce expression varies significantly. Short-term antibiotic exposure did not result in critical mutations that convert class 2 integrons into functional forms.
Authors
- Qingcao Li (ORCID: https://orcid.org/0000-0002-8769-8370)
- Rongqing Zhao (ORCID: https://orcid.org/0000-0002-4764-233X)
- Qiaoping Wu (ORCID: https://orcid.org/0000-0002-8796-2952)
- Jianqiang Xu (ORCID: https://orcid.org/0000-0002-1289-5943)
- Jinglu Ye
- Ye Yang
- Qian Sun (ORCID: https://orcid.org/0000-0003-3578-6210)
Institutions
- Ningbo University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fmicb.2025.1632813
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical and Health Research Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province