Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease
These findings demonstrate that systemic modulation of lipid and glucose metabolism can influence neurodegenerative and synaptic processes in AD. The results support metabolic interventions as a potential strategy to modify AD progression through peripheral-central metabolic crosstalk.
Authors
- Christiana C. Christodoulou (ORCID: https://orcid.org/0000-0002-6071-1715)
- Elena Panayiotou (ORCID: https://orcid.org/0000-0001-5211-3427)
- Demos Kynigopoulos (ORCID: https://orcid.org/0000-0003-1914-1340)
- Eleni Fella (ORCID: https://orcid.org/0000-0003-2858-9921)
- Menelaos Pipis (ORCID: https://orcid.org/0000-0003-0511-6515)
- Konstantinos Diskos
- Kleopas A. Kleopa (ORCID: https://orcid.org/0000-0002-4103-8094)
- Kyriaki Sidiropoulou (ORCID: https://orcid.org/0000-0001-7400-4678)
- Lucy Shahabian
- Revekka Papacharalampous
- Lida Evmorfia Vagiaki
Institutions
- University of Crete (GR)
- Institute of Molecular Biology and Biotechnology (BG)
- Cyprus Institute of Neurology and Genetics (CY)
- Foundation for Research and Technology Hellas (GR)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fnins.2025.1636624
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00