Label-free diagnostic procedure for hirschsprung’s disease to detect intestinal mucosal characteristics of aganglionosis by Raman spectroscopy with optimized decision algorithms
The proposed method and model show a high accuracy above 90% and a pseudo-blind examination involving three HSCR patients implies the feasibility for clinical application. (195 words).
Authors
- Hidefumi Shiroshita (ORCID: https://orcid.org/0000-0003-2800-8314)
- Tsutomu Daa (ORCID: https://orcid.org/0000-0001-5060-9883)
- Yuki Matsumoto (ORCID: https://orcid.org/0000-0003-0163-8105)
- Shun Onishi (ORCID: https://orcid.org/0000-0002-3984-3764)
- Kai Tamura
- Rena Yagi
- Satoshi Ieiri (ORCID: https://orcid.org/0000-0002-1250-093X)
- Yusuke Oshima (ORCID: https://orcid.org/0000-0002-2304-8600)
- Takashi Katagiri
- Katsuhiro Ogawa (ORCID: https://orcid.org/0009-0000-1811-8793)
- Masafumi Inomata (ORCID: https://orcid.org/0000-0002-8475-3688)
- Noritaka Fujisawa
- Tsuyoshi Etho
Institutions
- Kagoshima University (JP)
- Oita University (JP)
- Intellectual Property Institute (SI)
- University of Toyama (JP)
Publication Details
- Journal
- Lasers in Medical Science
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1007/s10103-025-04579-5
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science
- Moonshot Research and Development Program