Directed Evolution Restored Castrate Sensitivity in a Patient With Castrate Resistant Metastatic Prostate Cancer
This case suggests that evolution-informed strategies using population-based biomarkers to manipulate intra-tumoral evolution can restore castrate sensitivity in select patients.
Authors
- Robert A. Gatenby (ORCID: https://orcid.org/0000-0002-1621-1510)
- Dawn Lemanne (ORCID: https://orcid.org/0000-0003-3391-7694)
- Jill Gallaher (ORCID: https://orcid.org/0000-0001-9831-6676)
- Alexander R.A. Anderson (ORCID: https://orcid.org/0000-0002-2536-4383)
- Joel S. Brown (ORCID: https://orcid.org/0000-0001-9255-3355)
- Jeffrey Krolick
Institutions
- University of Arizona (US)
- Moffitt Cancer Center (US)
- Southern Oregon University (US)
Publication Details
- Journal
- The Prostate
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1002/pros.70038
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52