Self-Adaptive Sn–Fe Electron Pair Centers in Pt/SnFe<sub>2</sub>O<sub>4</sub> for Anti-Tumor Synergistic Therapy
Despite the multiple advantages of high tissue penetration depth, selectivity, and noninvasiveness of photothermal-assisted antitumor synergistic therapy, developing photothermal agents with multifunctional characteristics, desirable tumor therapeutic effects, and biological stability remains a key challenge. Herein, an electronic structure-regulated strategy is proposed to activate self-adaptive Sn-Fe electron pair centers (Sn<sup>2+</sup>/Sn<sup>4+</sup> and Fe<sup>2+</sup>/Fe<sup>3+</sup>) through loading the electron donor Pt (Pt/SFO-1, -2, -3, -4). Experimental and theoretical calculations indicate that abundant dynamic active centers can facilitate the production of reactive oxygen species (ROS), which enables Pt/SFO samples to possess catalase (CAT), peroxidase (POD), and oxidase (OXD) enzyme-like activities. Upon near-infrared (NIR) laser irradiation, Pt/SFO-2 with a Pt load of 0.9% achieves the highest ROS production, showing a 9-fold compared with SnFe<sub>2</sub>O<sub>4</sub> and implements the synergistic therapy of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The electronic state regulation of inorganic photothermal agents not only improves tumor therapeutic effects but also offers a novel strategy to regulate the electron structure of active centers.
Authors
- Yuzhu Hou (ORCID: https://orcid.org/0000-0001-8274-027X)
- Laiping Fang (ORCID: https://orcid.org/0009-0009-5827-9327)
- Ping’an Ma (ORCID: https://orcid.org/0000-0003-4198-5240)
- Keke Huang (ORCID: https://orcid.org/0000-0002-8995-2176)
- Kuo He (ORCID: https://orcid.org/0000-0002-4211-4968)
- Jianshi Du
- Qian Zhu (ORCID: https://orcid.org/0000-0002-2646-2604)
- Yuan Zhang (ORCID: https://orcid.org/0000-0001-7264-4161)
- Fei Yan (ORCID: https://orcid.org/0000-0003-4750-1200)
- Meichun Fu
- Zhiyu Shao (ORCID: https://orcid.org/0000-0001-7975-884X)
- Mengzhu Zhang (ORCID: https://orcid.org/0000-0003-2418-3027)
- Shuang Zhang (ORCID: https://orcid.org/0000-0003-1441-9884)
- Shouhua Feng
Institutions
- Union Hospital (HK)
- Jinan University (CN)
- Jilin University (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
- Czech Academy of Sciences, Institute of Inorganic Chemistry (CZ)
- Changchun University of Chinese Medicine (CN)
- Lymphatic Education & Research Network (US)
- Jilin Medical University (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
- Union Hospital (CN)
- Changchun University (CN)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1021/acsami.5c11501
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jilin Province
- National Natural Science Foundation of China
- Jilin University
- Department of Science and Technology of Jilin Province
- National Key Research and Development Program of China