Amyloidosis and liver. Review.
Amyloidosis is a rare disease, corresponding to a deposition of proteins in various tissues. Amyloid light-chain (AL) amyloidosis can involve the liver in 17% to 45% of patients. Diagnosis of liver disease is based on specific criteria, coupling alkaline phosphatases and hepatomegaly. Liver stiffness is altered in cases of heart involvement, and overall, in cases of liver involvement. Liver biopsy is generally avoided due to an important bleeding risk. Treatment is essentially based on stem cell transplantation and chemotherapy, with large progress during the last decade. Liver involvement recovery is generally diagnosed with a reduction in alkaline phosphatases and in liver size.
Authors
- J.F. Cadranel (ORCID: https://orcid.org/0000-0002-8442-4526)
- A. Cypierre
- V. Loustaud‐Ratti (ORCID: https://orcid.org/0000-0002-6951-0784)
- Paul Carrier (ORCID: https://orcid.org/0000-0001-9750-2506)
- Marilyne Debette‐Gratien (ORCID: https://orcid.org/0000-0001-6039-1355)
- Arnaud Jaccard (ORCID: https://orcid.org/0000-0001-8065-3199)
- Julie Abraham (ORCID: https://orcid.org/0000-0001-7514-9414)
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Centre Hospitalier Laennec (FR)
- Hôpital Dupuytren (FR)
- Université de Limoges (FR)
Publication Details
- Journal
- Exploration of Digestive Diseases
- Published
- 2025-08-28
- DOI
- https://doi.org/10.37349/edd.2025.100589
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00