RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation
We present evidence that the Scorpins act as partial antagonists and work together as one sophisticated rheostat to modulate the CTLH complex ubiquitylation output, which regulates cell proliferation and other key biological processes in NSCLC. These results suggest that the two Scorpins can be considered as targets for the treatment of NSCLC.
Authors
- Lino Tessarollo (ORCID: https://orcid.org/0000-0001-6420-772X)
- Anna Tessari (ORCID: https://orcid.org/0000-0002-6036-1954)
- Amer Ahmed (ORCID: https://orcid.org/0000-0002-0503-4045)
- Yasuko Kajimura (ORCID: https://orcid.org/0000-0002-0819-6904)
- Rosa Visone (ORCID: https://orcid.org/0000-0002-4993-0220)
- Vincenzo Coppola (ORCID: https://orcid.org/0000-0001-6163-1779)
- Brian D. Fries
- Jacob Kaufman
- Arturo Orlacchio (ORCID: https://orcid.org/0000-0002-6044-4258)
- Ruggiero Gorgoglione (ORCID: https://orcid.org/0000-0002-9860-0914)
- Lara Rizzotto (ORCID: https://orcid.org/0000-0002-2658-9103)
- David P. Carbone (ORCID: https://orcid.org/0000-0003-3002-1921)
- Giuseppe Fiermonte (ORCID: https://orcid.org/0000-0002-6764-9395)
- Shimaa Soliman (ORCID: https://orcid.org/0000-0001-6517-9847)
- Dario Palmieri (ORCID: https://orcid.org/0000-0002-0797-4268)
- Mike Freitas
- Alessia Lodi (ORCID: https://orcid.org/0000-0002-2104-5713)
- Liwen Zhang (ORCID: https://orcid.org/0000-0002-5077-9732)
- Joseph M. Amann
Institutions
- Northwestern University (US)
- Austin College (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- The Ohio State University Wexner Medical Center (US)
- University of Chieti-Pescara (IT)
- NYU Langone Health (US)
- Yamaguchi University Hospital (JP)
- LUM Jean Monnet University (IT)
- Center for Cancer Research (US)
- The Ohio State University (US)
- University of Bari Aldo Moro (IT)
- New York University (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13046-025-03491-8
- Citations
- 3
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Ohio State University
- Pelotonia
- National Institutes of Health
- National Cancer Institute