Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation
Arteriovenous fistula (AVF) failure remains a major barrier to long-term hemodialysis access in patients with end-stage kidney disease. This study identifies Sox17 as a key transcription factor mediating venous remodeling after AVF creation. Sox17 expression is elevated in mature human AVF and affects outward remodeling, wall thickening, and smooth muscle cell proliferation in a murine model. Sox17 knockdown results in impaired AVF maturation. These findings highlight Sox17 as a critical regulator of flow-mediated vascular adaptation and suggest that modulation of endothelial arterial identity through Sox17 may represent a novel therapeutic strategy to improve AVF outcomes.
Authors
- Alan Dardik (ORCID: https://orcid.org/0000-0001-5022-7367)
- Hualong Bai (ORCID: https://orcid.org/0000-0003-4039-414X)
- Masaki Kano (ORCID: https://orcid.org/0000-0002-3674-9852)
- Guohao Dai (ORCID: https://orcid.org/0000-0001-7346-2685)
- Yuichi Ohashi
- Kathleen A. Martin (ORCID: https://orcid.org/0000-0002-1748-0034)
- Roberto I. Vázquez-Padrón (ORCID: https://orcid.org/0000-0002-9370-276X)
- Yukihiko Aoyagi (ORCID: https://orcid.org/0000-0003-4165-0264)
- Andrew W. Schwartz (ORCID: https://orcid.org/0000-0003-3846-5877)
- Zhuo Li (ORCID: https://orcid.org/0000-0003-3692-8989)
- Luis González (ORCID: https://orcid.org/0000-0002-8456-6372)
- Bogdan Yatsula
- Cassius Iyad Ochoa Chaar
- Bryan Ho
- Cayetana Lazcano-Etchebarne
Institutions
- Northeastern University (US)
- Kyushu University (JP)
- University of Miami (US)
- Yale University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JVS Vascular Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jvssci.2025.100392
- Citations
- 1
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 2.52
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases