Lipids Engage a Kidney-Brain GDF15 Axis to Suppress Food Intake
Upper small intestine lipid infusion increases kidney, hepatic, and plasma growth differentiation factor 15 (GDF15) levels in chow but not high-fat rats. Upper small intestine lipid infusion lowers food intake in chow but not high-fat rats. Knockdown of kidney Gdf15 negates lipids to increase plasma GDF15 and lower feeding. Knockdown of GDNF family receptor α-like (Gfral) in the area postrema negates lipid anorectic effect.
Authors
- Tony K.T. Lam (ORCID: https://orcid.org/0000-0003-2908-3324)
- Kyla Bruce
- Chien‐Han Lai (ORCID: https://orcid.org/0000-0001-8259-1171)
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-6780-7293)
- Song‐Yang Zhang (ORCID: https://orcid.org/0000-0002-4356-897X)
- Melissa T. Wang
- Ameth N. Garrido
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Diabetes Canada (CA)
Publication Details
- Journal
- Diabetes
- Published
- 2025-08-28
- DOI
- https://doi.org/10.2337/db25-0174
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University Health Network Foundation