β‐elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1
l Imatinib resistance is associated with ferroptosis activity in GIST. l Combination of β-elemene and imatinib effectively treats gastrointestinal stromal tumours both in vivo and in vitro. l β-elemene promotes imatinib sensitivity in GIST through ferroptosis. l N6AMT1 is a potential target of β-elemene. l β-elemene targets N6AMT1 to promote imatinib sensitivity in imatinib-resistant GIST cells via the NRF2/HMOX1 axis.
Authors
- Wenhua Fan (ORCID: https://orcid.org/0000-0002-3588-2272)
- Qingjian Ou (ORCID: https://orcid.org/0000-0002-6881-8680)
- Rong Yang (ORCID: https://orcid.org/0000-0002-6112-3149)
- Weili Zhang (ORCID: https://orcid.org/0000-0003-4703-3486)
- Zhigang Hong
- Jiahua He (ORCID: https://orcid.org/0000-0002-9075-4978)
- Junzhong Lin (ORCID: https://orcid.org/0000-0003-4038-1939)
- Binyi Xiao (ORCID: https://orcid.org/0000-0002-7675-3207)
- Cong Li (ORCID: https://orcid.org/0000-0001-7778-7559)
- Xinyue Li (ORCID: https://orcid.org/0009-0000-9238-0458)
- Weifeng Wang (ORCID: https://orcid.org/0000-0001-9353-309X)
- Jun Chi (ORCID: https://orcid.org/0000-0002-9325-1196)
- Weihao Li (ORCID: https://orcid.org/0000-0003-4593-4264)
- Xiaojun Wu (ORCID: https://orcid.org/0000-0003-2926-3683)
- Chi Zhou (ORCID: https://orcid.org/0000-0002-8736-6501)
- Lan Jin
- Yujing Fang
- Kaixuan Zeng
- Zhizhong Pan (ORCID: https://orcid.org/0000-0002-5198-2919)
- Jianhong Peng
Institutions
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1002/ctm2.70438
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- Beijing Xisike Clinical Oncology Research Foundation
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Sun Yat-sen University Cancer Center