Cobalt-catalyzed regio- and stereoselective synthesis of atropisomers with vicinal C–C and C–N diaxes
A regio-, diastereo-, and enantioselective cobalt-catalyzed C-H activation/annulation of aromatic and alkenyl amides has been developed to access heterocycles featuring vicinal C-C and C-N diaxes. This strategy uniquely harnesses previously unexplored electronically unbiased internal alkynes and proceeds under mild conditions to deliver products in high yields with excellent regio- and stereocontrol.
Authors
- Shib Nath Saha (ORCID: https://orcid.org/0009-0007-6913-5375)
- Suman Ghosh (ORCID: https://orcid.org/0009-0004-1831-374X)
- Mainak Koner
- Mahiuddin Baidya (ORCID: https://orcid.org/0000-0001-9415-7137)
- Sanoop P. Chandrasekharan
- Partha Sarathi Saha (ORCID: https://orcid.org/0000-0002-4307-9287)
Institutions
- Indian Institute of Technology Madras (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04297f
- Citations
- 1
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.94