Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses
Protein expression differs more within hemispheres than across homologous regions, with distinct signatures in language-related brain areas. Functional connectivity strength correlates with protein expression similarity, showing left-right asymmetry in excitatory/inhibitory synaptic regulation (GRIA1/GRIA4). Right-hemispheric homologs compensate for left-hemispheric language-area damage in glioma patients, linking molecular profiles to functional reorganization.
Authors
- Luhao Yang
- Gong‐Hong Wei (ORCID: https://orcid.org/0000-0001-6546-9334)
- Fangyuan Gong (ORCID: https://orcid.org/0000-0003-4889-3867)
- Wenke Fan
- Binke Yuan (ORCID: https://orcid.org/0000-0002-9839-8453)
- Qiong Liu (ORCID: https://orcid.org/0009-0005-8241-8252)
- Shuolei Bu
- Zixian Wang (ORCID: https://orcid.org/0000-0002-7950-787X)
- Guomin Zhou (ORCID: https://orcid.org/0000-0001-5071-4528)
- Yong He (ORCID: https://orcid.org/0000-0002-7039-2850)
- Maurice A. Curtis (ORCID: https://orcid.org/0000-0003-4496-0233)
- Linya You (ORCID: https://orcid.org/0000-0002-2569-0269)
- Weiwei Xian (ORCID: https://orcid.org/0000-0003-0066-0685)
- Wanjing Li (ORCID: https://orcid.org/0009-0006-8391-1337)
- Russell G. Snell (ORCID: https://orcid.org/0000-0002-8166-4014)
- Tianye Jia (ORCID: https://orcid.org/0000-0001-5399-2953)
- Jinsong Wu (ORCID: https://orcid.org/0000-0001-9204-4489)
- Kemin Zhu (ORCID: https://orcid.org/0000-0003-1603-9869)
- Zheng Chen (ORCID: https://orcid.org/0009-0000-8971-0567)
- Jiali Chen (ORCID: https://orcid.org/0000-0001-7376-3322)
- Wensheng Li (ORCID: https://orcid.org/0000-0003-4160-9317)
- Jing Yan (ORCID: https://orcid.org/0000-0001-6245-7434)
- Jiaxuan Yang (ORCID: https://orcid.org/0000-0002-0672-1330)
- Shuai Wu (ORCID: https://orcid.org/0000-0002-2776-1710)
- Fengjiao Li (ORCID: https://orcid.org/0000-0002-6153-7747)
- Jingliang Cheng (ORCID: https://orcid.org/0000-0002-2867-3237)
- Lianglong Sun (ORCID: https://orcid.org/0009-0007-0164-0893)
- Weijiang Zhang
- Yien Huang
- Zhixin Bai
- Guoquan Yan
Institutions
- Shanghai Medical College of Fudan University (CN)
- University of Auckland (NZ)
- King's College London (GB)
- South China Normal University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Beijing Normal University (CN)
- Auckland University of Technology (NZ)
- Shanghai Institute for Science of Science (CN)
- Ministry of Education (RW)
- Fudan University Shanghai Cancer Center (CN)
- Chinese Institute for Brain Research (CN)
- Suzhou Institute of Systems Medicine (CN)
- Shanghai Institute of Computing Technology (CN)
- Brain Research New Zealand (NZ)
- First Affiliated Hospital of Zhengzhou University (CN)
- The First People's Hospital of Xiaoshan District, Hangzhou (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Southampton (GB)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1002/ctm2.70449
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Municipal Education Commission
- National Office for Philosophy and Social Sciences
- National Key Research and Development Program of China