Visible-Light-Driven Photoredox-Catalyzed Radical Cyclization via a TEMPO-Intercepted Cascade: Regioselective and Access to Cyclopentene Skeletons
A visible-light-driven regioselective intramolecular cyclization and oxidation cascade of γ-alkynyl β-sulfonylester is developed. This metal-free approach efficiently affords synthetically useful cyclopentene and cyclohexene skeletons under mild conditions, with TEMPO acting as a dual electron and oxygen atom donor. Mechanism investigations support a radical cyclization/TEMPO-trapping cascade.
Authors
- Mingyou Hu (ORCID: https://orcid.org/0000-0002-7892-7338)
- Xin‐Hua Duan (ORCID: https://orcid.org/0000-0002-1527-5934)
- Le Liu (ORCID: https://orcid.org/0000-0001-8954-9478)
- Qi Jiang
- Keyuan Zhang
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1021/acs.orglett.5c03155
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xi’an Jiaotong University
- Fundamental Research Funds for the Central Universities