Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension
EV-N and EV-H reduced RVSP, but only EV-H improved RVH and RV outflow diameter, increased the PAT/PET ratio, and downregulated GSK3β protein levels. EVs from hypoxia-preconditioned MSCs demonstrated greater cardioprotective effects than those from normoxia-conditioned MSCs.
Authors
- Nazareth N. Rocha (ORCID: https://orcid.org/0000-0003-0921-8068)
- Carla Medeiros da Silva
- Sarah A.S. Alves (ORCID: https://orcid.org/0000-0001-6879-3973)
- Pedro Leme Silva (ORCID: https://orcid.org/0000-0001-5838-4949)
- Christina Maeda Takiya (ORCID: https://orcid.org/0000-0002-8019-628X)
- Renata Trabach Santos (ORCID: https://orcid.org/0009-0004-5462-2152)
- Celso Caruso Neves
- Douglas E. Teixeira
- Sabrina Sodré de Souza Serra
- Fernanda Ferreira Cruz (ORCID: https://orcid.org/0000-0001-9443-3648)
- Beatriz Toja de Miranda (ORCID: https://orcid.org/0000-0001-9945-5758)
- Rodrigo Gonzaga Veras (ORCID: https://orcid.org/0000-0003-4501-090X)
- Miria Gomes Pereira (ORCID: https://orcid.org/0000-0001-9103-0448)
- Patrícia R. M. Rocco (ORCID: https://orcid.org/0000-0003-1412-7136)
- Maria Eduarda de Sá Freire Onofre
- Mitch A. Garcia
- Cássia L. Braga
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Fluminense (BR)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13287-025-04604-y
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro