Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential
This study demonstrated that UCMSC-Exos could rejuvenate senescent JBMMSCs by activating autophagy via the regulation of PI3K/AKT/mTOR pathway, and enhance bone repair in aged rats. UCMSC-Exos hold potential as a cell-free therapeutic tool for anti-aging treatments and regenerative medicine, particularly for age-related skeletal disorders.
Authors
- An‐Ping Li (ORCID: https://orcid.org/0000-0003-4400-7493)
- Haihui Wang (ORCID: https://orcid.org/0000-0001-6345-0349)
- Chuan Cai
- Xinjing Wang (ORCID: https://orcid.org/0009-0003-2745-7262)
- Shuang Wu (ORCID: https://orcid.org/0000-0001-7618-5476)
- Tong Zhang (ORCID: https://orcid.org/0000-0001-8043-237X)
- Hongkun Li (ORCID: https://orcid.org/0000-0003-1979-4763)
- Shuaichen Li
- Sunxin Zhou
- Nuo Xu (ORCID: https://orcid.org/0009-0006-6428-8068)
Institutions
- Chinese PLA General Hospital (CN)
- Hainan General Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13287-025-04587-w
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42