Donor-dependent regulation of type II and X collagen deposition by early modulation of miR-335-5p and miR-1246 during chondrogenic commitment
These results suggest that miR-335-5p and miR-1246 have a regulatory effect on endochondral ossification, and genes regulated by miR-335-5p are involved in TGF-β signalling. The function of these miRNAs in human bone formation and repair should be further investigated to validate their potential role as prognostic markers in fracture healing.
Authors
- Simone Berger (ORCID: https://orcid.org/0000-0002-3572-7205)
- Martin James Stoddart (ORCID: https://orcid.org/0000-0002-9538-1517)
- Franziska Lioba Breulmann (ORCID: https://orcid.org/0000-0002-4162-1642)
- Elena Della Bella (ORCID: https://orcid.org/0000-0001-5151-7390)
Institutions
- University of Zurich (CH)
- AO Foundation (CH)
- Universitätsklinik Balgrist (CH)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13287-025-04589-8
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AO Foundation
- Directorate for Biological Sciences