GSH-responsive magnetic imaging for <i>in situ</i> monitoring of tumor chemodynamic therapy
Chemodynamic therapy (CDT) is a promising treatment modality that utilizes highly toxic hydroxyl radicals (˙OH) to kill tumor cells <i>in situ</i>. However, real-time monitoring of drug distribution and therapeutic response remains a challenge, hindering the optimization of personalized treatment regimens. Here, we developed a glutathione (GSH)-responsive nanoreactor (FA-Mn NR), with integrated magnetic resonance imaging (MRI) functionality for self-enhanced CDT. The nanoreactor undergoes GSH-triggered Mn<sup>2+</sup> release, which simultaneously functions as an MRI contrast agent and catalyzes hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) to produce additional ˙OH, thereby achieving synergistic CDT amplification. The study demonstrates a theranostic platform combining GSH-responsive imaging guidance with enhanced therapeutic efficacy, presenting a novel approach for cancer therapy.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0001-6937-5562)
- Jun Lu (ORCID: https://orcid.org/0000-0002-9347-7793)
- Zhongyao Jiang (ORCID: https://orcid.org/0000-0002-9387-844X)
- Yue‐Qin Tang (ORCID: https://orcid.org/0000-0001-6872-1099)
- Ping Li (ORCID: https://orcid.org/0000-0002-4926-3835)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-8934-3346)
- Hui Wang (ORCID: https://orcid.org/0000-0002-6464-3262)
- Bo Tang (ORCID: https://orcid.org/0000-0002-8712-7025)
- Xinyu Chen (ORCID: https://orcid.org/0000-0002-4589-4111)
Institutions
- Shandong Normal University (CN)
- Qilu Hospital of Shandong University (CN)
- Laoshan Laboratory
Publication Details
- Journal
- Chemical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5sc04436g
- Citations
- 3
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Government of Shandong Province