Opposing profiles of Netrin-1 and adiponectin in metabolic inflammation and insulin resistance
Circulating Netrin-1 and adiponectin display opposing profiles aligned with pro- versus anti-inflammatory signaling in metabolic dysfunction. These findings support the Netrin-1/adiponectin axis as an immunometabolic marker set in early IR states. The cross-sectional design limits causal inference; longitudinal studies integrating tissue-level measurements are warranted.
Authors
- Daniel Osmar Suárez-Rico (ORCID: https://orcid.org/0000-0002-9237-213X)
- Edy David Rubio Arellano (ORCID: https://orcid.org/0000-0002-3337-7934)
- Tannia Isabel Campos-Bayardo (ORCID: https://orcid.org/0000-0002-2004-7899)
- Alberto Beltrán-Ramírez (ORCID: https://orcid.org/0000-0001-7892-9125)
- Jesús Jonathan García-Galindo (ORCID: https://orcid.org/0000-0002-2120-1819)
- Sara Pascoe-González
- Luis D. López-Murillo
- Luis Ricardo Balleza-Alejandri (ORCID: https://orcid.org/0000-0002-1540-9365)
- Emiliano Peña-Durán (ORCID: https://orcid.org/0009-0009-3364-0913)
- María G. Ramos-Zavala
- Alfredo Huerta-Huerta
Institutions
- Universidad de Guadalajara (MX)
- Hospital Médica Sur (MX)
- Hospital Civil de Guadalajara (MX)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fphar.2025.1632956
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- Universidad de Guadalajara