Exercise improves endothelial progenitor cell’s function in mice with Type 2 diabetes via gut microbiota modulation
Our findings suggest that exercise improves EPC's function in diabetic mice via gut microbiota modulation, with FMT synergistically enhancing GLP-1 secretion. The identified microbiota (Prevotellaceae, Ligilactobacillus, Akkermansia) may serve as therapeutic targets for T2DM(T2DM) and its cardiovascular complications.
Authors
- Liang Tang (ORCID: https://orcid.org/0000-0002-5988-8660)
- M Zhang (ORCID: https://orcid.org/0009-0004-3876-5444)
- Zheng Huang (ORCID: https://orcid.org/0000-0003-0876-5369)
- H. Chen
- Qiong Yang (ORCID: https://orcid.org/0000-0002-9234-7102)
- Xia Dai (ORCID: https://orcid.org/0000-0003-2839-7698)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Baise University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.3389/fcimb.2025.1606652
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00