Cytokine release and NLRP3 inflammasome activation induced by low-abundance oral bacterial biofilms
These findings highlight the immunostimulatory potential of LAB species, particularly their ability to activate NLRP3 and drive inflammation. The differential activation of NLRP3/Caspase-1 by biofilms and supernatants suggests distinct pathogenic mechanisms. Targeting such mechanisms/pathways could offer new therapeutic strategies to mitigate inflammation linked to oral infections.
Authors
- Manal Abu Al-Melh (ORCID: https://orcid.org/0000-0001-5958-6497)
- Maribasappa Karched (ORCID: https://orcid.org/0000-0001-8927-6617)
- Radhika Guleri (ORCID: https://orcid.org/0000-0003-3613-4783)
- Muawia A. Qudeimat (ORCID: https://orcid.org/0000-0002-2800-0307)
Institutions
- American Academy of Arts and Sciences (US)
- Kuwait University (KW)
- American University of Kuwait (KW)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1080/20002297.2025.2552167
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Kuwait University